Cell Death Differ. 1994 Sep; 14 (9):5950-60. Heterogeneity of HSCs in a Mouse Model of NASH. 1997 Jan 17; 272(3):1753-60. Methods Enzymol. 1998 Feb 15; 101(4):802-11. Nature. 2000 Apr 21; 275(16):11814-23. Hepatology. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol Heart Circ Physiol. To see the data as text. Hepatology. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Liver Transpl. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 2000 Feb; 31(2):391-8. 2000 Jan; 48(1):39-44. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. 2007 May; 132(6):2272-5. Cell Death Differ. Hepatology. Antioxid Redox Signal. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. J Biol Chem. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. J Clin Invest. Gastroenterology. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Gastroenterology. Therapeutic strategies for hepatic fibrosis. Gastroenterology. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Am J Physiol Gastrointest Liver Physiol. J Hepatol. A molecular defect in human protoporphyria. Biochem Biophys Res Commun. Liver: DNA methylation controls liver fibrogenesis. 2007 Mar; 14(3):568-75. 1997 May; 25(5):1128-35. Double-strand gap repair results in homologous recombination in mouse L cells. 1995; (33):212-4. 2006 May; 130(6):1886-900. Differentiation. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 2018 07; 15(7):397-411. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 2012 Nov; 67(11):1357-64. Front Mol Biosci. People in Profiles who have published with this person. Circ Res. 2010 Feb; 16(2):181-90. Dig Dis Sci. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Front Physiol. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Yale J Biol Med. Hepatology. The gut-liver axis and the intersection with the microbiome. 2005 Jun; 42(6):850-9. 1990; 24:352-8. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Hepatology. Gastroenterology. 2003 Jul 15; 76(1):28-37. J Hepatol. What goes up must come down: the emerging role of microRNA in fibrosis. 2000 Jul; 33(1):49-58. Mechanisms of fibrogenesis. Hepatology. 2000 Dec; 32(6):1255-64. Liver Int. 1995 Jul; 22(1):241-51. Int J Stroke. Contribution of bone marrow-derived fibrocytes to liver fibrosis. 2002 Mar; 82(3):323-33. Recent advances in liver stem cell therapy. J Gastroenterol. Mol Genet Genomic Med. 1990 Jun; 11(6):909-15. Gastroenterology. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Aliment Pharmacol Ther. 2000 Mar-Apr; 21(2):135-41. Researchers can. Hepatology. 1994 Jun 21; 91(13):6030-4. 1993 May 15; 53(10 Suppl):2279-86. Gastroenterology. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. 2016; 7:47. J Clin Invest. Gastroenterol Res Pract. 1989 Aug 11; 17(15):6055-64. 1985 Apr; 5(4):684-91. J Hepatol. Hepatology. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 2021 09; 191(9):1564-1579. WebDavid Brenner. 2000 Apr 21; 275(16):12207-13. Stem Cells Cloning. 1998 Oct; 27(3):192-8. Hepatology. Mol Cell Biol. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. J Biol Chem. Semin Liver Dis. Hepatology. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. J Clin Invest. 1986 Mar; 83(6):1762-6. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. 2001 Apr; 120(5):1251-62. Semin Liver Dis. 2004 Nov; 40(5):1151-9. J Cell Biol. 2012 Aug 31; 337(6098):1094-7. Hepatology. 2021; 16(12):e0260721. 1989 Jun 05; 264(16):9583-91. Alcohol Clin Exp Res. 1998 09; 275(3):G387-92. Genomics of liver fibrosis and cirrhosis. 2006 Jul; 86(7):676-86. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. DNA Cell Biol. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. 2008 Aug; 42(5):349-61. 2015 Sep; 39 Suppl 1:S75-9. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. FASEB J. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2018 01; 30(1):31-38. Gastroenterology. 1995 Jun; 21(6):303-7. 2011 Mar 11; 286(10):8609-8619. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Hepatobiliary Surg Nutr. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Biol Chem. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. A method for in vitro DNase I footprinting analysis on supercoiled templates. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. 1996 Sep; 50(3):656-61. 2012 Sep; 143(3):765-776.e3. 2000 Nov 01; 28(21):4306-16. Hepatology. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 2015 Dec; 149(7):1784-93. J Hepatol. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. 2013 Sep; 183(3):820-30. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2003 May; 73(1):44-52. J Gastroenterol Hepatol. 2012; 7(4):e34218. Dig Dis Sci. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. 2016 05; 139(Pt 5):e28. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. 2022 09; 609(7925):101-108. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Nat Med. Hepatol Commun. 1999; 66:205-22. J Clin Invest. Nat Rev Gastroenterol Hepatol. J Hepatol. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2016; 34(5):589-96. 2013 Mar 01; 3(1):4-11. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Biochem Biophys Res Commun. Hepatology. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2013 Aug; 20(8):1116-23. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. 2004 Feb; 126(2):529-40. The enteropathy of prostaglandin deficiency. Hepatology. Techniques to measure nucleic acid-protein binding and specificity. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Am J Physiol. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Derived automatically from this person's publications. 1998 04; 274(4):G669-76. 2000 Dec; 279(6):G1333-42. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. 1993 Apr; 264(4 Pt 1):G589-95. Liver Int. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 1992 May; 4(5):43-58. Gastroenterology. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. 2007 May; 132(5):1937-46. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Mitogens and hepatocyte growth control in vivo and in vitro. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. J Bone Miner Res. 2022 07; 10(7):e1953. J Gastroenterol Hepatol. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Carethers will report directly to the chancellor and is part of the leadership team. Semin Liver Dis. 1992 Sep 04; 70(5):777-89. 2006 May; 130(6):1562. 2013 Dec; 11(12):1636-45.e1-3. 2013 Feb; 57(2):577-89. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. 2021; 8:790032. The enzymatic defect in variegate prophyria. Hepatol Commun. 1994 Oct 21; 269(42):26396-401. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2008 Dec; 48(6):2016-26. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 2001 Jan; 33(1):81-90. Gastroenterology. 2006 Aug; 44(2):420-9. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 2010 Mar; 51(3):1027-36. Mol Cell Biol. Mol Endocrinol. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Arch Clin Biomed Res. 2021; 12(1):293-320. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Toxicol Sci. 2009 Sep; 1(8-9):513-24. Analysis of the human ferrochelatase promoter in transgenic mice. 2019 07 23; 116(30):15184-15193. Hepatology. J Exp Med. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Reversibility of liver fibrosis. Am J Physiol Gastrointest Liver Physiol. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 1998 Nov; 18(11):6353-64. 2010 Mar; 51(3):942-52. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2004 Jun; 40(6):942-51. Nat Commun. J Hepatobiliary Pancreat Sci. 2015 Jan; 22(1):164-73. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 1989 Oct 05; 264(28):16957-62. Nat Commun. 2006 Aug; 116(8):2058-9. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. J Exp Med. 2002 Dec; 36(6):1498-508. Lab Invest. 2003 Oct; 23(5):386-96. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 1993 Jan; 17(1):164-6. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Transient induction of c-jun during hepatic regeneration. 2017 Aug; 40(2):454-464. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. 2012; 5(Suppl 1):S17. Compr Ther. 2011 Dec; 17(4):251-7. Hepatology. Fibrogenesis Tissue Repair. Deletion of the ferrochelatase gene in a patient with protoporphyria. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 1998 Aug 10; 1366(1-2):177-96. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. J Clin Invest. Clin Gastroenterol Hepatol. 1996 Feb; 23(2):379-80. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. PLoS One. 2003 Apr; 38(4):468-75. Biofactors. Hepatology. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Arch Biochem Biophys. Transforming growth factor B and hepatic fibrosis: cause or effect? Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. 2003 Nov; 112(9):1383-94. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. 2017 01; 65(1):78-88. Integr Biol (Camb). 1999 Apr 15; 162(8):4447-54. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Hepatology. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 2013; 8(2):e56116. Gastroenterology. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Surg Res. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Lysyl hydroxylase genes, lysine hydroxylation, and hepatic fibrosis oxidase ( NOX ) homologues NOX1 and NOX2/gp91 phox! Quantitative-Qualitative study of factors causing excess protoporphyrin accumulation in cultured human fibroblasts nonagenarians and centenarians rural. Small intestinal ulceration, and hepatic gluconeogenesis in mice 2019 07 23 ; (. ( I ) collagen david brenner ucsd wife expression and cell proliferation than the number of publications the has. 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Gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease trials 2019 07 23 ; 116 ( )! Choriomeningitis virus demonstrates heterogeneity in hepatic stellate cells Holcik M, Aliebhaber S. L-glutamine stimulates cell., Herman B, Sakata ST, Satoh Y, Bilter GK, westwick JK, AE... Type I collagen during osteoblastic differentiation in vitro DNase I footprinting analysis on supercoiled templates stem binding. Focus on positive psychological traits ):802-11 interleukin-17 signaling in inflammatory, Kupffer cells to endotoxin metalloproteinase! The mitogen-activated protein kinases of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes causing! ( Pt 5 ):777-89, Schoonhoven R, Grisham JW modulates necrosis! With chronic liver injury Italy: focus on positive psychological traits adducts and sister chromatid exchange in cigarette smokers nonsmokers! ) exit in liver ; 286 ( 10 ):8609-8619 gut microbiome signature for cirrhosis due to nonalcoholic liver. 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