The liver received the highest dose (0.360 mSv/MBq), followed by the gallbladder wall (0.155 mSv/MBq). The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications. 2015 Aug 20;10(8):e0135389. What is the real truth? Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. Luciferase signals at the injection sites, most likely reflecting distribution to the lymph nodes draining the injection sites, peaked 6h post injection with signals of approximately 10 000 times of buffer control animals. Implementation status of clinical biodistribution by formulation in locally administered product group as of September 2018. At vascular endothelium, ACE2 performs conversion of angiotensin II to angiotensin (17). Read summaries of real world examples of proejcts completed by SGW Designworks. When that happens, it can do one of two things: it can either cause platelets to clump, and that can lead to clottingthats exactly why weve been seeing clotting disorders associated with these vaccines. Bittorf P, Bergmann T, Merlin S, Olgasi C, Pullig O, Sanzenbacher R, Zierau M, Walles H, Follenzi A, Braspenning J. Mol Ther Methods Clin Dev. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. The signals from the liver region peaked 6h post injection and decreased to background levels 48h after injection. As reported by TrialSite News:7. Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. This site needs JavaScript to work properly. It also modulates the adhesion of platelets to the endothelium. What did the initial Pfizer biodistribution studies show? Family threatened, his life threatened. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. Click to access 672212000_30300AMX00231_I100_1.pdf, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated The Courtenay Turner Podcast. (LogOut/ In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. Other research suggests the SARS-CoV-2 spike protein can have a serious impact on your mitochondrial function, which is imperative for good health, innate immunity and disease prevention of all kinds. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. In vivo luciferase expression was detected at different timepoints at the injection sites and in the liver region indicating drainage to the liver. The effective dose was 0.0705 mSv/MBq. For example, in the development of new compounds for PET ( positron emission tomography) scanning, a radioactive isotope is chemically joined with a peptide (subunit of a protein ). Pfizer - Confidential Covid-19 Vaccine Biodistribution report. 2021 Sep 8;22(18):9705. doi: 10.3390/ijms22189705. J Altern Complement Med. Dysfunctional mitochondria predispose to oxidative stress and loss of cellular function and vitality. Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease which is it, did they or did they now know that the spike protein was a toxin/pathogenic for a long time? Using Luciferine to follow biodistribution of a product is common practice. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). Next, LPP formulated with mRNA encoding luciferase as a model. It has been one of the hardest blogs for me to write and why you did not receive a blog last week! The site is secure. The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. , with maximum concentrations observed at 8-48 hours post-dose. Even my doctor, who is against it, could not tell me public sources. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. The study is titled, "Placebo-controlled randomized double-blind (evaluators, patients) multi-facility joint parallel-group comparison . Women have reported changes in menstruation after taking mRNA vaccines. All Rights Reserved. Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. Using mRNA programmed to produce luciferase protein, as well as mRNA tagged with a radioactive label, Pfizer showed that the majority of the mRNA initially remain near the injection site, but within hours become widely distributed within the body.9. Sunlight also has other benefits besides making vitamin D. Use time-restricted eating and eat all your meals for the day within a six- to eight-hour window. Data were . (LogOut/ To combat the toxicity of the spike protein, youll want to optimize autophagy, which may help digest and remove the spike proteins. Documents obtained from Japanese regulatory agency reveal that Pfizer biodistribution studies showed that mRNA and spike proteins circulate widely throughout the body. The short answer is: absolutely not. The study 514559 was aimed to examine the biodistribution of ChAdOx1 nCoV-19 in bone marrow, brain, spinal cord, sciatic nerve, and other body tissues. It is a toxin that can cause damage in our body if it gets into circulation. Tags:Japan Pfizer spike proteins vaccines. Vitamin D Part I: Is Vitamin D really a vitamin? Avoid all vegetable oils and processed foods. Together with international scientists, he requested access to the "biodistribution study" from the Japanese regulatory agency that is labeled "Pfizer Confidential." The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. government site. The take-home message Kendrick delivers is that If you damage the lining of blood vessel walls, blood clots are far more likely to form. 1 Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, Japan. Since any protein in the blood will concentrate in breast milk, observing that the spike protein gets into circulation is even more disturbing. As of August 23, 2021, the Pfizer-BioNTech inoculation is now approved under the brand name Comirnaty. Although no regulatory authority has recognized ICH as an adverse event associated with tozinameran (BNT162b2, Pfizer-BioNTech), fatal and non-fatal cases have been reported. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. The bioanalysis methods appear to be adequate. If any decision is difficult to make, it is usually because one does not have enough facts. 8.6. This toxin, Bridle notes, can cause cardiovascular damage and infertility a claim echoed by researchers such as Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D., whom Ive interviewed about these issues. Is it a safe assumption that it stays in the shoulder muscle? It is certainly understandable why the vaccine was rushed into use as an experimental product under emergency use authority, but these new findings suggest that routine quality testing issues were overlooked in the rush to authorize use. Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. As expected with an mRNA product, the luciferase expression was transient and decreased over time. 2018;7(1):7886. According to this study, there was no difference in ovarian function between those who were infected with the Covid-19 and those who were not. HHS Vulnerability Disclosure, Help Biomedicines. Consistent data shows the virus is less severe than influenza in children, strengthening the argument of do kids need the vaccine? Voicing his concern, Bridle asserts: Thats not how this is supposed to work; our kids should not be the guinea pigs. Remember to check the date when the fact-check you are reading was published before sharing it. Walker VE, Walker DM, Meng Q, McDonald JD, Scott BR, Seilkop SK, Claffey DJ, Upton PB, Powley MW, Swenberg JA, Henderson RF; Health Review Committee. After spending 20 hours of research, I found there are. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Clipboard, Search History, and several other advanced features are temporarily unavailable. I had the same link as you but now it is not active. The mean concentrations and tissue distribution pattern were broadly similar between the sexes. Image . Standard studies designed to assess these risks were not performed in compliance with accepted empirical research standards. 8.8. However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells. Additionally, the EMA document states, "Biodistribution: Several literature reports indicate that LNP-formulated RNAs can distribute rather nonspecifically to several organs such as spleen, heart, kidney, lung and brain. Thrombocytopenia is a commonly-reported side effect of COVID-19 vaccines, as are blood clots, strokes and lethal heart attacks all of which are pointing toward spike proteins causing vascular damage. 2015;43(1):115125. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. Mikovits goes so far as to call the spike protein a bioweapon, as it is a disease-causing agent that demolishes innate immunity and exhausts your natural killer (NK) cells ability to determine which cells are infected and which arent. No safety pharmacology studies were conducted with BNT162b2. Very often, the damage is caused by the immune system going on the attack, damaging blood vessel walls, and removing several of the anti-clotting mechanisms. The end result can be lethal, and this chain of events is exactly what these COVID-19 vaccines are setting into motion. In my interview with Seneff and Mikovits (see earlier hyperlink), they both stressed that the key danger both in COVID-19 and with the vaccines is the spike protein itself. Please enable it to take advantage of the complete set of features! eCollection 2015. SARS-CoV-2 MRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of Pharmacokinetic Study. Biodistribution (BD) analysis is performed to determine the distribution and the persistence of the vector/virus to target and nontarget tissues following direct in vivo administration in animals. What is the length of time the vaccine exists in the body after vaccination? An in vivo biodistribution study was performed in a rat model with CCl 4-induced liver fibrosis to evaluate the uptake of IGF2R peptide-modified nanocomplex in the fibrotic liver . Any objections based on the experimental status of this vaccine are now moot. We now know spike protein gets into circulation. Time-restricted eating will upregulate autophagy, while sauna therapy, which upregulates heat shock proteins, will help refold misfolded proteins and also tag damaged proteins and target them for removal. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). 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The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. The Comirnaty/Pfizer-BioNTech Fact Sheet for Healthcare Providers Administering Vaccine clearly states that pre-authorization Pfizer-BioNTech vaccine and the Comirnaty vaccine are equivalent. Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active pharmaceutical ingredient encapsulated. Appl Microbiol Biotechnol. The Japanese biodistribution study of Pfizer's mRNA vaccine has also found that 0.02% and 0.009% of the vaccine administered dose ended up in the brain at 2-hour and 48-hour, respectively: 2022 Apr 7;10(4):869. doi: 10.3390/biomedicines10040869. Why are these questions surfacing now? The accumulation in the ovaries is shown on the second page. 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