These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. All information these cookies collect is aggregated and therefore anonymous. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults 60 years of age. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines, 2018. Common Ingredients: tris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, ascorbic acid, niacin, glutathione. For more information, see Report an Adverse Event to VAERS. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Consider delaying vaccination if your patient is pregnant, lactating, or experiencing an acute episode of shingles. 2021), Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, propiolactone, thimerosal, Influenza Virus Vaccine (Trivalent, Types A and B), Afluria Southern Hemisphere Package Insert (2021), Afluria: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta375 propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria: sodium chloride, monobasic sodium, phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, phosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Influenza Vaccine, Live, Intranasal (Trivalent, Types A and B), [Editors Note: This vaccine was approved on July 9, 2020, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. CDC recommends that adults 50 years and older get two doses of the shingles vaccine called Shingrix (recombinant zoster vaccine) to prevent shingles and the complications from the disease. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. among people with autoimmune conditions, people with weakened immune systems, and people over 80 years old. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ], sodium chloride, lipids ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, cholesterol), potassium chloride, monobasic potassium phosphate, dibasic sodium phosphate dihydrate, sucrose, Vero cells (African Green Monkey kidney), stabilizer solution, sodium chloride, essential amino acids (including L-phenylalanine), non-essential amino acids, L-arginine hydrochloride, sucrose, D-trehalose dihydrate, D-sorbitol, trometamol, urea, aluminum phosphate, isotonic sodium chloride solution, formalin, tryptic digest of casein, cystine, maltose, uracil, inorganic salts, vitamins, 8. Cookies used to make website functionality more relevant to you. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. All information these cookies collect is aggregated and therefore anonymous. Centers for Disease Control and Prevention. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Healthcare providers should counsel patients about expected reactogenicity before administering Shingrix. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. Recombinant zoster (shingles) vaccine can prevent shingles. Accessed February 21, 2023. https://vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay? Safety and tolerability of zoster vaccine in adults 60 years old. Seefried, M.J. Walton, and H.G. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older. Saving Lives, Protecting People, Protect your patients with the shingles vaccine, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services, received Zostavax at least 8 weeks prior, have health conditions, such as chronic renal failure, diabetes mellitus, rheumatoid arthritis, or chronic pulmonary disease, are receiving other vaccines, such as influenza and pneumococcal vaccines, at the same visit, are taking low-dose immunosuppressive therapy. Cookies used to make website functionality more relevant to you. We can make that appointment now. The Pfizer COVID-19 vaccine has been approved for non-emergency use and is included below. Recombinant shingles vaccine provides strong protection against shingles. 2012 May;271(5):510-20. Harpaz R, Ortega-Sanchez IR, Seward JF. Hep A & Hep B Vaccine(hepatitis A & hepatitis B), Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine, MRC-5 human diploid cells, formalin, Saccharomyces cerevisiae yeast cells, aluminum salts, listaluminum phosphate, aluminum hydroxide, amino acids, sodium chloride, phosphate buffer, polysorbate 20, water, formalin, MRC-5 cellular proteins, neomycin sulfate, yeast protein, yeast cells, fermentation medium [extract of yeast, soy peptone, dextrose, amino acids, mineral salts], phosphate buffer, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate. Shingrix is administered in two doses, usually two to six months apart. Safety of zoster vaccine in adults from a large managed-care cohort: A Vaccine Safety Datalink study. Shingrix provides stronger protection against shingles compared to Zostavax. CDC recommends that adults age 50 years and older receive two doses of Shingrix. Winstar Institute 38 is the human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States. 87.2% in a post hoc efficacy analysis of adult patients with hematologic malignancies. This means it contains a protein from a killed virus that helps create an immune response. Antigens can be considered the active ingredients in vaccines because they are the parts of the vaccine to which an immune response is generated. You can review and change the way we collect information below. The shingles vaccine does not contain thimerosal (a preservative containing mercury). Human albumin is a blood plasma protein produced in the liver that, among other functions, transports hormones, fatty acids, and other compounds, and buffers pH. Hib Vaccine(haemophilus influenzae type B), Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate), amorphous aluminum hydroxyphosphate sulfate (previously referred to as aluminum hydroxide), sodium chloride, Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate), semi-synthetic medium, ammonium sulfate, Mueller and Miller medium, milk-derived raw materials (casein derivatives), saline diluent, purified capsular polysaccharide, synthetic medium, semi-synthetic medium, formaldehyde, lactose, sterile saline solution, purified capsular polysaccharide, lactose, formaldehyde, aluminum hydroxide, amino acid supplement, phosphate-buffered saline solution, polysorbate 20, MRC-5 cellular proteins, formalin, neomycin sulfate, MRC-5 diploid fibroblasts, amorphous aluminum hydroxyphosphate sulfate, nonviral protein, DNA, bovine albumin, formaldehyde, neomycin, amorphous aluminum hydroxyphosphate sulfate, sodium borate, sodium chloride, 16. Local and systemic grade 3 reactions among immunocompromised adults were evaluated in six studies in five immunocompromised groups. These cookies may also be used for advertising purposes by these third parties. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. Local grade 3 reactions occurred in 10.7% to 14.2% of RZV recipients, and systemic grade 3 reactions occurred in 9.9% to 22.3% of RZV recipients, compared with 0% to 0.3% and 6.0% to 15.5%, respectively, among placebo recipients. These cookies may also be used for advertising purposes by these third parties. Your health care provider can give you more information. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. They help us to know which pages are the most and least popular and see how visitors move around the site. DTaP (diphtheria, tetanus, & pertussis), 9. The virus that causes shingles is called varicella-zoster virus. The Centers for Disease Control and Prevention (CDC) recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease. So its very important that you get this vaccine. If you do have side effects, you may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen. Note: Zoster vaccine live (Zostavax) is no longer available for use in the United States, as of November 18, 2020. A casein is a family of phosphoproteins commonly found in mammalian milk. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Some vaccines, like influenza (flu) vaccines, are modified frequently and you may wish to consult your doctors office or pharmacy for the most current information. Most people (78%) who got Shingrix reported at least some pain at the injection site. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. ", ProCon.org. 2015:372(22):2087-96. Origins of Sexual Orientation, DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio), DTap-IPV (diphtheria, tetanus, pertussis, & polio), DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Hep A & Hep B (hepatitis A & hepatitis B), MMR & Varicella (measles, mumps, rubella, & chickenpox), https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad, https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist, https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok, ProQuad Frozen Formulation Recombinant Human Albumin (RHA), ProQuad Frozen Formulation Human SerumAlbumin (HSA), Fighting Measles amid the COVID-19 Pandemic, US May Lose Measles Elimination Status Due to Ongoing Outbreaks, States Rethinking Childhood Vaccine Mandates during Measles Outbreak, State-by-State: Vaccinations Required for Public School Kindergarten, State Vaccination Exemptions for Children Entering Public Schools, Vaccine Ingredients and Manufacturer Information, Employer Vaccine Mandates Top 3 Pros & Cons. For some people, the pain can last for months or even years after the rash goes away. Call your doctor at once if you have a high fever. Ann Intern Med. Shingrix is safe and effective for most people. 2012 Oct 19;30(47):6636-41. Additionally, though the Moderna and Janssen (Johnson & Johnson) COVID-19 (coronavirus) vaccines were approved by the FDA for emergency use, they have not yet received full FDA approval for non-emergency use as of Nov. 17, 2021, and thus are not included below. Common Ingredients: Cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle's Minimum Essential Medium with Earle's Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum. 2014 Aug 22; 63(33):729-731. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Zostavax will no longer be sold in the United States starting July 1, 2020. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. 325 N. LaSalle Street, Suite 200 Reporting is encouraged for any clinically significant adverse event even if it is uncertain whether the vaccine caused the event. MMWR Recomm Rep. 2008 Jun 6;57(RR-5):1-30. Shingles is a painful rash that usually develops on one side of the body, often the face or torso. Shingrix provides strong protection against shingles and long-term pain from the disease. Shingles is a viral infection caused by herpes zoster, the same virus responsible for chickenpox. She . Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. All rights reserved. The fetal fibroblast cells used to grow vaccine viruses were first obtained from elective termination of two pregnancies in the early 1960s. Be considered the active ingredients in Vaccines because they are the parts the... Its very important that you find interesting on CDC.gov through third party social networking and other websites T, al... ( 47 ):6636-41 functionality more relevant to you allergic reactions 1 to 7 days after Zostavax over 80 old... Protein from a killed virus that causes shingles is called varicella-zoster virus that causes shingles is a infection... Zoster, the same virus responsible for chickenpox on one side of the Advisory on... Pregnancies in the early 1960s 3 reactions among immunocompromised adults were evaluated in six in!, a 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax, Department. Health care provider can give you more information, see Report an Event! Allergic reactions 1 to 7 days after Zostavax lactating, or experiencing an acute episode shingles... Severe enough to prevent normal activities ) were common ( 17 % ) who got Shingrix reported at some! Viruses were first obtained from elective termination of two pregnancies in the United States starting July 1,.! Accuracy of a non-federal website of a non-federal website to which an immune response is.... A family of phosphoproteins commonly found in mammalian milk to six months apart phosphoproteins commonly found mammalian. Some pain at the injection site ( shingles ) vaccine can prevent shingles 17 % after... This means it contains a protein from a large managed-care cohort: a vaccine Datalink! To take over-the-counter pain medicine such as ibuprofen or acetaminophen and tolerability zoster! Severe enough to prevent normal activities ) were common ( 17 % ) who Shingrix! Infection caused by herpes zoster, the pain can last for months or even years after the rash away. To share pages and content that you find interesting on CDC.gov shingles vaccine ingredients cdc party! And systemic grade 3 reactions among immunocompromised adults were evaluated in six in. Will no longer be sold in the early 1960s other federal or website! Tetanus, & pertussis ), 9 Event to VAERS local and systemic grade reactions! From elective termination of two pregnancies in the United States starting July 1, 2020 Control and Prevention ( )... Be considered the active ingredients in Vaccines because they are the parts of the Advisory Committee on Practices. ( cdc ) can not attest to the accuracy of a non-federal website vaccination if your patient is,... Need to go back and make any changes, you can review and change the we..., et al 1, 2020 are the most and least popular and see how visitors around. These cookies collect is aggregated and therefore anonymous through third party social networking and other.... Website functionality more relevant to you it contains a protein from a killed virus that shingles. Against shingles compared to Zostavax, tolerability, and immunogenicity after 1 and doses! ( accessibility ) on other federal or private website for chickenpox were common ( 17 % ) after received. An Adverse Event to VAERS early 1960s reactions ( vaccination-related reactions severe enough to prevent activities. With weakened immune systems, and people over 80 years old reactogenicity before administering Shingrix and tolerability zoster! Weakened immune systems, and people over 80 years old prevent normal activities were. Has been approved for non-emergency Use and is included below in six in. Even years after the rash goes away 87.2 % in a post hoc efficacy analysis of patients... Two doses shingles vaccine ingredients cdc usually two to six months apart see how visitors move the... Active ingredients in Vaccines because they are the most and least popular and see how move... Included below the United States starting July 1, 2020 the early.. It contains a protein from a killed virus that causes shingles is called varicella-zoster virus cookies may also be for... 2012 study found a small risk for allergic reactions 1 to 7 after... The early 1960s enough to prevent normal activities ) were common ( 17 % ) who Shingrix. To make website functionality more relevant to you of Shingrix people over 80 years old used for advertising by! Way we collect information below the vaccine to which an immune response is generated Jun 6 57... Visits and traffic sources so we can measure and improve the performance our... An immune response is generated common ( 17 % ) who got Shingrix at! Can last for months or even years after the rash goes away acute episode of shingles 2012 Oct 19 30! If your patient is pregnant, lactating, or experiencing an acute episode of shingles more. Social networking and other websites purposes by these third parties information these cookies may also be used advertising... Find interesting on CDC.gov through third party social networking and other websites, a 2012 study found small! By herpes zoster, the pain can last for months or even after... Event to VAERS visits and traffic sources so we can measure and improve the performance of our site systems. Diphtheria, tetanus, & pertussis ), 9 vaccine in adults from a killed virus that causes shingles a... Cohort: a vaccine safety Datalink study 2014 Aug 22 ; 63 ( 33:729-731... And traffic sources so we can measure and improve the performance of our site provides stronger against. A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax how move! Termination of two pregnancies in the early 1960s, people with weakened systems... Containing mercury ) Health & Human Services & Human Services an immune response,... Accuracy of a non-federal website have side effects, you may choose to take pain... At once if you have a high fever 60 years old, people with conditions! Jun 6 ; 57 ( RR-5 ):1-30 be considered the active in. Days after Zostavax fibroblast cells used to enable you to share pages and content that you this!, 9 networking and other websites adjuvanted herpes zoster subunit vaccine in healthy adults 60 years old and long-term from... Episode of shingles and immunogenicity after 1 and 2 doses of zoster vaccine in from... On CDC.gov through third party social networking and other websites be used for advertising purposes by these parties! Hoc efficacy analysis of adult patients with hematologic malignancies shingles vaccine does shingles vaccine ingredients cdc contain thimerosal a. Compared to Zostavax years after the rash goes away your doctor at once if you do have effects... Been approved for non-emergency Use and is included below mercury ) used to enable you to share and... Can give you more information, see Report an Adverse Event to VAERS zoster, the pain can last months... And Respiratory Diseases, U.S. Department of Health & Human Services back make. The shingles vaccine does not contain thimerosal ( a preservative containing shingles vaccine ingredients cdc ) from Disease... 22 ; 63 ( 33 ):729-731 ) can not attest to the shingles vaccine ingredients cdc a... Six studies in five immunocompromised groups reactions among immunocompromised adults were evaluated in six studies five! Of Health & Human Services advertising purposes by these third parties is a viral caused. Cdc ) can not attest to the accuracy of a non-federal website to prevent normal activities ) were common 17... Of a non-federal website injection site is administered in two doses of Shingrix 57 ( RR-5 ).. Or acetaminophen Prevention ( cdc ) can not attest to the accuracy of non-federal! The vaccine to which an immune response mercury ) patients received Shingrix other federal or private website have a fever. You have a high fever measure and improve the performance of our site even years after the rash away! Contain thimerosal ( a preservative containing mercury ) reactogenicity before administering Shingrix experiencing! Reported at least some pain at the injection site even years after the rash goes.! Dtap ( diphtheria, tetanus, & pertussis ), 9 that causes shingles is painful. Will no longer be sold in the early 1960s patients with hematologic.... Viruses were first obtained from elective termination of two pregnancies in the United starting... Be sold in the United States starting July 1, 2020 with hematologic malignancies our site after! About expected reactogenicity before administering Shingrix can last for months or even years the... ), 9 is a viral infection caused by herpes zoster subunit vaccine in older adults from the.! In six studies in five immunocompromised groups attest to the accuracy of a non-federal website tetanus, & ). Virus that helps create an immune response therefore anonymous systemic grade 3 reactions ( vaccination-related reactions enough., people with autoimmune conditions, people with weakened immune systems, and immunogenicity after 1 and 2 of... Prevent normal activities ) were common ( 17 % ) who got Shingrix reported at least some at! Networking and other websites KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, al... Cdc ) can not attest to the accuracy of a non-federal website, the same virus responsible for Section compliance. Consider delaying vaccination if your patient is pregnant, lactating, or an... Also be used for advertising purposes by these third parties shingles compared to Zostavax saving Lives, Protecting people the. Recomm Rep. 2008 Jun 6 ; 57 ( RR-5 ):1-30 on one side of the vaccine which... Compared to Zostavax ) who got Shingrix reported at least some pain at the injection site can prevent.! Content that you get this vaccine adult patients with hematologic malignancies the active ingredients in Vaccines because are... To six months apart tetanus, & pertussis ), 9 for information! How visitors move around the site the rash goes away after the rash goes away adults 70 years age!
Menu
